NFL Week 1 odds, picks, schedule, how to watch, streaming: Expert picks, teasers, survivor picks and more

The 2021 NFL regular season is finally here, which means it’s time to win money. Well, you’ll win money, because you have come to the right place when it comes to expert picks against the spread. While your friends are losing money on favorites they were certain would cover in Week 1, you did your research and knew better. This is your study guide, compiled by the experts.


Each week, we’ll collect all of the best picks and gambling content from and SportsLine in one place, so you can get picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more.

Enjoy our run-through of Week 1! All odds via Caesars Sportsbook.

Which picks can you make with confidence in Week 1? And which Super Bowl contender goes down hard? Visit SportsLine, as their incredible model simulates every NFL game 10,000 times and is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago.

Cardinals at Titans

Time: Sunday, 1 p.m. ET (CBS), stream on Paramount+ (click here)
Open: Titans -2.5, O/U 51.5
Current: Titans -3, O/U 53.5

“This was my upset call during my early look-ahead story from a few weeks back and I continue to like the spot the Cardinals are in to begin the season. They have an offense littered with weapons and a quarterback in Kyler Murray that should be able to avoid whatever pressure the Titans are able to apply as they look to improve in that area following a dreadful 2020 season on that side of the ball. Meanwhile, both of Tennessee’s top two receivers A.J. Brown and Julio Jones have been limited throughout the summer due to various injuries. While I expect both to play, I’m not quite sure they’ll be 100%, which will hurt Ryan Tannehill’s chances of success in the passing game.

“Meanwhile, Tennessee is another team that has historically struggled out of the gate. In its last five Week 1 contests, the Titans are 1-4 ATS and 1-5 ATS in their last six games in September.”

CBS Sports NFL writer Tyler Sullivan is calling an upset! Check out the rest of his Week 1 picks, here.

Jaguars at Texans

Time: Sunday, 1 p.m. ET (CBS), stream on Paramount+ (click here)
Open: Jaguars -2, O/U 46
Current: Jaguars -3, O/U 45.5

SportsLine’s Mike Tierney is all over teasers this season. If you’re unfamiliar, a teaser is a play that involves at least two games with more favorable point spreads than are offered with a traditional bet. Our picks will be limited to two-game, six-point teasers, meaning that a half-dozen points will be tacked on in favor of our chosen team in each game.

We can tell you he likes teasing the Texans up to +9. Head on over to SportsLine to see what else he’s suggesting.

Chargers at Washington

Time: Sunday, 1 p.m. ET (CBS), stream on Paramount+ (click here)
Open: Chargers -2, O/U 44.5
Current: Washington -1, O/U 44.5

“Justin Herbert has never played a game in an NFL stadium against an NFL defense with a full crowd cheering against him and being loud and being raucous. That should be a factor for him, Burrow and Tua. Not only that, but you’re dealing with a new offense, and a new offensive coordinator and so all that coordination that you were able to do easily in empty stadiums is now suddenly going to be much, much more difficult and I think we could see Herbert struggle a little bit against an elite defense. So give me Washington all day. Love the Football Team here.”

That’s Will Brinson’s take from the Pick Six Podcast, where he, Pete Prisco and R.J. White broke down all the games from a gambling perspective and gave out best bets on Friday — as they do every week. Give it a listen below and subscribe for great NFL content in your feed daily.


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